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Creators/Authors contains: "Benjamin, Candace"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, Chemical Science)
    We can alter the release kinetics of highly stabilized biomacromolecules in both skin and plant tissues to allow for either instant release or slow release simply by changing the typeof gas used in a pneumatic delivery jet. 
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  2. ; ; ; ; ; ; ; ; ; ; et al (, Journal of the American Chemical Society)
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  3. ; ; ; ; ; ; ; ; ; ; et al (, ACS Nano)
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  4. ; ; ; ; ; ; ; (, Nanoscale)
    The emergence of viral nanotechnology over the preceding two decades has created a number of intellectually captivating possible translational applications; however, the in vitro fate of the viral nanoparticles in cells remains an open question. Herein, we investigate the stability and lifetime of virus-like particle (VLP) Qβ—a representative and popular VLP for several applications—following cellular uptake. By exploiting the available functional handles on the viral surface, we have orthogonally installed the known FRET pair, FITC and Rhodamine B, to gain insight of the particle's behavior in vitro . Based on these data, we believe VLPs undergo aggregation in addition to the anticipated proteolysis within a few hours of cellular uptake. 
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  5. ; ; ; ; ; ; ; (, Bioconjugate Chemistry)
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  6. ; ; ; ; ; ; (, Supramolecular Chemistry)
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  7. ; ; ; ; ; ; ; ; ; ; et al (, Chemical Science)
    Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo . We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus. 
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  8. ; ; ; ; ; ; ; (, Journal of the American Chemical Society)
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  9. ; ; ; ; ; ; ; ; ; (, ACS Applied Materials & Interfaces)
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  10. ; ; ; ; ; ; ; ; ; ; et al (, Molecular Pharmaceutics)
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